HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1055
+	Hs
		665604 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB2_HUMAN (20-1055): 0: 1304: 100.00
+	Hs
		349222 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA4_HUMAN (6-982): 0: 1152: 58.33
+	Hs
		348673 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA7_HUMAN (6-982): 0: 1154: 57.46
+	Hs
		348528 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA3_HUMAN (16-980): 0: 1152: 56.37
+	Hs
		1070202 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA7_HUMAN (6-982): 0: 1154: 57.46
+	Hs
		665398 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA3_HUMAN (16-980): 0: 1152: 56.37
+	Hs
		349144 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA2_HUMAN (18-980): 0: 1041: 47.98
+	Hs
		348527 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA2_HUMAN (18-980): 0: 1041: 47.98
+	Hs
		872534 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB4_HUMAN (1-979): 0: 1046: 55.53
+	Hs
		665242 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA2_HUMAN (18-980): 0: 1041: 47.98
+	Hs
		349123 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA1_HUMAN (12-976): 0: 961: 41.21
+	Hs
		349876 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		EPHA1_HUMAN (12-976): 0: 961: 41.21
+	Hs
		349065 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		INSR_HUMAN (277-941): 5.94e-150: 484: 24.02
+	Hs
		348472 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		INSR_HUMAN (277-941): 5.94e-150: 484: 24.02
+	Hs
		349800 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		INSR_HUMAN (277-941): 5.94e-150: 484: 24.02
+	Hs
		349808 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31
+	Hs
		349069 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		YES_HUMAN (572-881): 5.77e-65: 231: 42.95
+	Hs
		348473 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		YES_HUMAN (572-881): 5.77e-65: 231: 42.95
+	Hs
		433358 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		YES_HUMAN (572-881): 5.77e-65: 231: 42.95
+	Hs
		349806 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		YES_HUMAN (572-881): 5.77e-65: 231: 42.95