HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression and 1 others more... GO:0019003 - GDP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 221
+	Hs
		349201 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00
+	Hs
		349231 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RAB1A_HUMAN (1-220): 3.18e-84: 250: 34.69
+	Hs
		348579 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00
+	Hs
		348601 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RAB1A_HUMAN (1-220): 3.18e-84: 250: 34.69
+	Mm
		895595 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB8B_MOUSE (6-219): 2.5e-86: 255: 40.65
+	Hs
		119846 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RB27B_HUMAN (1-221): 6.03e-81: 242: 71.04
+	Mm
		722682 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46
+	Hs
		349344 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RB11B_HUMAN (3-219): 1.64e-79: 239: 33.78
+	Hs
		918874 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RAB1A_HUMAN (1-220): 3.18e-84: 250: 34.69
+	Mm
		918986 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB1A_MOUSE (1-220): 3.18e-84: 250: 34.69
+	Mm
		1161509 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB1B_MOUSE (3-219): 3.02e-83: 247: 34.56
+	Hs
		348682 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RB11B_HUMAN (3-219): 1.64e-79: 239: 33.78
+	Zm
		73944 B4FAE1_MAIZE (4-187): 8.1e-78: 232: 32.82		B4FAE1_MAIZE (3-220): 1.43e-86: 256: 35.32
+	Hs
		350016 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RAB14_HUMAN (2-221): 6.59e-80: 239: 31.39
+	Hs
		350033 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RB11A_HUMAN (3-219): 9.56e-80: 239: 34.55
+	Mm
		926076 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB3A_MOUSE (2-219): 7.24e-57: 181: 42.20
+	Hs
		349228 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RAB10_HUMAN (1-184): 9.74e-50: 162: 43.48
+	Mm
		877193 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB8A_MOUSE (6-187): 1.34e-52: 170: 46.70
+	Hs
		895491 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		RAB10_HUMAN (1-184): 9.74e-50: 162: 43.48
+	Mm
		895579 RAB35_MOUSE (4-187): 1.09e-82: 244: 31.28		RAB10_MOUSE (1-184): 9.74e-50: 162: 43.48