HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	20709748, 11948427, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 607
+	Hs
		349206 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		348587 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854133 RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854088 RAP1A_HUMAN (1-165): 7.83e-63: 194: 58.08		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Dm
		51795 Q962I2_DROME (4-178): 1.03e-60: 189: 51.14		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51789 RALA_DROME (4-182): 3.4e-60: 187: 52.22		GDS1_DROME (62-536): 0: 540: 31.27