HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 603
+	Hs
		348590 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861761 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861690 RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Ce
		711483 RAP1_CAEEL (1-189): 6.18e-77: 229: 52.63		PLK1_CAEEL (22-599): 0: 536: 50.58
+	Ce
		136854 RB11A_CAEEL (4-188): 1.02e-71: 217: 30.50		PLK1_CAEEL (22-599): 0: 536: 50.58
+	Hs
		682177 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		349916 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		682159 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		349336 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		348674 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		350188 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		349992 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44