HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30639242, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 504
+	Hs
		349238 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00
+	Hs
		348609 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00
+	Hs
		349305 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		348808 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		CADM4_HUMAN (38-426): 3.78e-56: 194: 16.92
+	Hs
		1045043 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		211414 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SIGL6_HUMAN (25-503): 2.38e-51: 182: 13.94
+	Hs
		350155 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		895070 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		349775 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		349043 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		1070491 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		349617 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		CADM1_HUMAN (41-289): 2.77e-25: 109: 21.18
+	Hs
		349572 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		348867 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		350746 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		1070344 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		350572 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ROBO2_HUMAN (24-494): 2.34e-25: 112: 11.56
+	Hs
		350513 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		CADM1_HUMAN (41-289): 2.77e-25: 109: 21.18
+	Hs
		350455 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		350405 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20