HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: FGD1 (P98174)
FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)
Gene: FGD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 961
+	Hs
		349422 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FGD6_HUMAN (46-920): 1.03e-122: 408: 23.01
+	Hs
		350280 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FGD6_HUMAN (46-920): 1.03e-122: 408: 23.01
+	Hs
		299225 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		FARP2_HUMAN (183-949): 1.68e-100: 340: 19.80
+	Hs
		349105 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		VAV_HUMAN (297-865): 1.19e-96: 325: 16.00
+	Hs
		349026 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		FARP1_HUMAN (142-933): 6.73e-95: 325: 19.75
+	Hs
		1070476 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		FARP1_HUMAN (142-933): 6.73e-95: 325: 19.75
+	Hs
		299226 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FARP2_HUMAN (183-949): 1.68e-100: 340: 19.80
+	Hs
		350721 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FARP1_HUMAN (142-933): 6.73e-95: 325: 19.75
+	Hs
		349341 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ITSN1_HUMAN (2-742): 6.63e-81: 290: 16.80
+	Hs
		349421 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ARHGI_HUMAN (18-707): 1.64e-81: 290: 17.82
+	Hs
		1070208 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ITSN1_HUMAN (2-742): 6.63e-81: 290: 16.80
+	Hs
		350441 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ARHGQ_HUMAN (2-712): 1.24e-85: 295: 17.03
+	Hs
		349391 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ARHGG_HUMAN (332-687): 6.2e-77: 268: 23.93
+	Hs
		350195 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ITSN1_HUMAN (2-742): 6.63e-81: 290: 16.80
+	Hs
		349481 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NGEF_HUMAN (231-684): 9.09e-75: 262: 21.58
+	Hs
		914091 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		ITSN1_HUMAN (2-742): 6.63e-81: 290: 16.80
+	Hs
		279866 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TRIO_HUMAN (59-374): 2.08e-09: 64.1: 12.66
+	Hs
		279827 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TRIO_HUMAN (59-374): 2.08e-09: 64.1: 12.66
+	Hs
		279852 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		TRIO_HUMAN (59-374): 2.08e-09: 64.1: 12.66