HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016601 - Rac protein signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1591
+	Hs
		349282 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		348640 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		1022394 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		895058 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		279866 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		349105 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		VAV_HUMAN (954-1525): 4.75e-87: 306: 15.72
+	Hs
		279827 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		349422 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		279852 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		TRIO_HUMAN (700-1587): 3.07e-89: 325: 17.13
+	Hs
		349341 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		1070208 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		350280 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FGD6_HUMAN (764-1451): 2.66e-80: 294: 16.11
+	Hs
		350195 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Hs
		914091 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		ITSN1_HUMAN (991-1425): 2.43e-76: 283: 18.08
+	Dm
		1229130 Q962I2_DROME (4-178): 1.03e-60: 189: 51.14		Q8MSP7_DROME (1041-1240): 5.83e-14: 79.7: 29.50
+	Dm
		71594 RALA_DROME (4-182): 3.4e-60: 187: 52.22		B3DN64_DROME (1041-1240): 5.77e-14: 79.7: 29.50
+	Sc
		350788 RAS2_YEAST (3-164): 2.5e-58: 187: 64.42		CDC24_YEAST (1043-1244): 6.36e-14: 79.3: 29.56
+	Sc
		350758 RAS1_YEAST (3-164): 4.46e-57: 183: 63.19		CDC24_YEAST (1043-1244): 6.36e-14: 79.3: 29.56