HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: IQGA2 (Q13576)
Ras GTPase-activating-like protein IQGAP2
Gene: IQGAP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1575
+	Hs
		1040022 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		IQGA2_HUMAN (1-1575): 0: 1336: 100.00
+	Hs
		809313 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		349964 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		1070477 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MYO5A_HUMAN (230-1465): 4.4e-122: 425: 12.23
+	Hs
		1061919 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		GAPD1_HUMAN (784-1396): 1.9e-92: 332: 16.51
+	Hs
		349392 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		349121 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		348719 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		348509 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		349718 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		1070242 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		348993 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		1070446 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		350243 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		1070348 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61
+	Hs
		349875 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		349120 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RASA1_HUMAN (789-1263): 8.94e-66: 245: 16.08
+	Hs
		348508 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		RASA1_HUMAN (789-1263): 8.94e-66: 245: 16.08
+	Hs
		349874 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		RASA1_HUMAN (789-1263): 8.94e-66: 245: 16.08
+	Hs
		201878 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		RASL2_HUMAN (854-1207): 5.63e-21: 102: 18.92