HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0043495 - protein-membrane adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 337
+	Hs
		153904 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		348876 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Hs
		349277 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		349510 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		INADL_HUMAN (3-129): 2.49e-13: 73: 21.81
+	Hs
		349319 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		348639 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		348663 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1021495 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		349543 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DLG3_HUMAN (89-220): 8.62e-10: 61.9: 17.99
+	Hs
		1049954 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		350465 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Hs
		1020162 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		350124 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		350374 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		INADL_HUMAN (3-129): 2.49e-13: 73: 21.81
+	Hs
		350166 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		895057 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		350121 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Hs
		350232 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		914039 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		350420 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DLG3_HUMAN (89-220): 8.62e-10: 61.9: 17.99