HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_13~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1721
+	Hs
		349341 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		1070208 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		914091 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Hs
		279866 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TRIO_HUMAN (154-1590): 1.54e-71: 269: 10.81
+	Hs
		279827 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TRIO_HUMAN (154-1590): 1.54e-71: 269: 10.81
+	Hs
		350075 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FGD1_HUMAN (1066-1664): 3.93e-73: 267: 16.32
+	Hs
		506558 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		BCR_HUMAN (732-1682): 1.5e-71: 266: 12.45
+	Hs
		279852 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		TRIO_HUMAN (154-1590): 1.54e-71: 269: 10.81
+	Hs
		349391 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ARHGG_HUMAN (1224-1491): 2.63e-20: 99.8: 29.18
+	Hs
		350441 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ARHGQ_HUMAN (1227-1491): 1.61e-22: 107: 27.17
+	Hs
		914425 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		EP15R_HUMAN (545-929): 2.95e-11: 70.8: 14.14
+	Hs
		557649 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75