HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0043495 - protein-membrane adaptor activity GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 519
+	Hs
		349543 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27
+	Hs
		1020162 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84
+	Hs
		350420 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27
+	Hs
		350121 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84
+	Hs
		349319 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		348876 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89
+	Hs
		348663 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		349277 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		1049954 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		348639 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		1021495 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		349510 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		INADL_HUMAN (30-389): 9.81e-13: 73.3: 13.55
+	Hs
		350465 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89
+	Hs
		350166 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		153904 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		350190 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		350124 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		895057 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		914039 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Hs
		350374 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		INADL_HUMAN (30-389): 9.81e-13: 73.3: 13.55