HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: FGD6 (Q6ZV73)
FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)
Gene: FGD6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1430
+	Hs
		349422 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FGD6_HUMAN (1-1430): 0: 1161: 100.00
+	Hs
		349341 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ITSN1_HUMAN (200-1195): 7.48e-113: 394: 13.93
+	Hs
		350075 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FGD1_HUMAN (520-1427): 1.47e-125: 416: 21.78
+	Hs
		1070208 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ITSN1_HUMAN (200-1195): 7.48e-113: 394: 13.93
+	Hs
		350195 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ITSN1_HUMAN (200-1195): 7.48e-113: 394: 13.93
+	Hs
		299225 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		FARP2_HUMAN (649-1428): 9.83e-95: 332: 21.12
+	Hs
		299226 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FARP2_HUMAN (649-1428): 9.83e-95: 332: 21.12
+	Hs
		349105 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		VAV_HUMAN (808-1271): 2.44e-83: 294: 15.91
+	Hs
		349481 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NGEF_HUMAN (594-1220): 7.05e-75: 266: 16.76
+	Hs
		349280 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ABR_HUMAN (802-1189): 9.14e-68: 248: 18.34
+	Hs
		350441 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ARHGQ_HUMAN (641-1178): 9.99e-76: 272: 16.96
+	Hs
		279866 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TRIO_HUMAN (848-1370): 4.98e-52: 204: 17.70
+	Hs
		279827 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TRIO_HUMAN (848-1370): 4.98e-52: 204: 17.70
+	Hs
		349026 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		FARP1_HUMAN (1284-1428): 6.76e-21: 101: 21.77
+	Hs
		1070476 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		FARP1_HUMAN (1284-1428): 6.76e-21: 101: 21.77
+	Hs
		350721 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FARP1_HUMAN (1284-1428): 6.76e-21: 101: 21.77
+	Hs
		313539 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ZFYV9_HUMAN (1206-1307): 2.84e-15: 84: 40.95
+	Hs
		164122 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ARHGA_HUMAN (874-1078): 1.11e-13: 78.6: 27.75
+	Hs
		313486 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ZFYV9_HUMAN (1206-1307): 2.84e-15: 84: 40.95
+	Hs
		350295 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ZFY16_HUMAN (1212-1322): 1.14e-14: 82: 41.59