HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	30442766, 30639242, 30194290, 34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 788
+	Hs
		349425 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		348748 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		1070265 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		895142 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		914159 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		349139 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		348523 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647896 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		1070428 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Hs
		349893 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647857 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647864 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		350628 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Rn
		871206 RAB14_RAT (4-184): 3.77e-72: 218: 29.51		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00