HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: ARHGQ (Q96DR7)
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)
Gene: ARHGEF26

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 871
+	Hs
		349481 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NGEF_HUMAN (176-868): 2.83e-113: 364: 26.96
+	Hs
		349391 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ARHGG_HUMAN (179-871): 7.61e-106: 344: 41.30
+	Hs
		164122 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ARHGA_HUMAN (69-758): 2.51e-95: 328: 18.40
+	Hs
		349422 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FGD6_HUMAN (32-818): 2.52e-83: 294: 14.68
+	Hs
		164114 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		ARHGA_HUMAN (69-758): 2.51e-95: 328: 18.40
+	Hs
		349341 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		ITSN1_HUMAN (6-789): 5.8e-80: 285: 15.93
+	Hs
		1070208 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ITSN1_HUMAN (6-789): 5.8e-80: 285: 15.93
+	Hs
		349026 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Hs
		349105 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		VAV_HUMAN (376-806): 2.68e-78: 273: 16.20
+	Hs
		350280 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FGD6_HUMAN (32-818): 2.52e-83: 294: 14.68
+	Hs
		1070476 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Hs
		350195 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ITSN1_HUMAN (6-789): 5.8e-80: 285: 15.93
+	Hs
		350721 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		FARP1_HUMAN (217-863): 5.87e-79: 278: 15.16
+	Hs
		914091 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		ITSN1_HUMAN (6-789): 5.8e-80: 285: 15.93
+	Hs
		279866 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		TRIO_HUMAN (23-231): 4.97e-09: 62.4: 14.83
+	Hs
		279827 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TRIO_HUMAN (23-231): 4.97e-09: 62.4: 14.83
+	Hs
		279852 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		TRIO_HUMAN (23-231): 4.97e-09: 62.4: 14.83