HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30442766, 30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1116
+	Hs
		349655 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		348930 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		1070402 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		1070251 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		350257 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		350706 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52
+	Dm
		442996 RAS1_DROME (1-165): 9.63e-88: 257: 85.46		Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37
+	Hs
		349739 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		349013 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		1066121 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38
+	Hs
		348876 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		350696 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		348931 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		1070403 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		350465 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		350565 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		348866 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		349631 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		WWP1_HUMAN (3-240): 7.83e-24: 110: 14.94
+	Hs
		350454 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		350405 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15