HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 795
+	Hs
		1070428 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK1_HUMAN (1-795): 0: 775: 100.00
+	Hs
		349425 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		348748 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		349139 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		348523 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		1070265 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647896 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		350286 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		895142 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		349893 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		647857 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		914159 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647864 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Rn
		871206 RAB14_RAT (4-184): 3.77e-72: 218: 29.51		AAPK1_RAT (34-579): 1.58e-142: 433: 28.29