HitPredict

Interactor 1: RAS2 (P01120)
Ras-like protein 2 (EC 3.6.5.2)
Gene: RAS2

Interactor 2: CYAA (P08678)
Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase)
Gene: CYR1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	10048790, 10594005, 10747953, 37968396
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 322 Sc			1 2026
+	Hs
		232757 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		PHLP1_HUMAN (399-1764): 6.54e-179: 593: 16.16
+	At
		955322 RAB1C_ARATH (6-218): 8.26e-78: 238: 28.51		BRL2_ARATH (528-1126): 1.51e-94: 335: 13.67
+	Hs
		350324 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		LRC8A_HUMAN (978-1321): 3.71e-41: 167: 18.36
+	Hs
		914066 RB11A_HUMAN (4-218): 3.25e-86: 259: 27.32		SCRIB_HUMAN (1040-1270): 2.9e-10: 68.2: 27.35
+	Hs
		914297 RB11A_HUMAN (4-218): 3.25e-86: 259: 27.32		ERBIN_HUMAN (1040-1271): 3.37e-10: 67.8: 24.54
+	Hs
		349737 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		SHOC2_HUMAN (837-1271): 7.07e-24: 110: 28.70
+	Hs
		350693 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		SHOC2_HUMAN (837-1271): 7.07e-24: 110: 28.70
+	Hs
		350499 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		LRRC1_HUMAN (809-1122): 2.62e-22: 105: 26.17
+	Hs
		156102 RASM_HUMAN (7-174): 2.29e-54: 178: 55.62		SHOC2_HUMAN (837-1271): 7.07e-24: 110: 28.70
+	Ce
		612369 LET60_CAEEL (10-172): 4.01e-54: 176: 63.80		SHOC2_CAEEL (797-1132): 2.28e-23: 108: 25.36
+	Hs
		349319 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		SCRIB_HUMAN (1040-1270): 2.9e-10: 68.2: 27.35
+	Hs
		350166 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		SCRIB_HUMAN (1040-1270): 2.9e-10: 68.2: 27.35
+	Hs
		349581 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		ERBIN_HUMAN (1040-1271): 3.37e-10: 67.8: 24.54
+	Hs
		350468 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		ERBIN_HUMAN (1040-1271): 3.37e-10: 67.8: 24.54
+	Hs
		349426 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		LRC8D_HUMAN (869-1269): 3.47e-10: 67.4: 24.32
+	Hs
		348663 RASN_HUMAN (10-190): 7.41e-58: 186: 61.54		SCRIB_HUMAN (1040-1270): 2.9e-10: 68.2: 27.35
+	Hs
		348879 RASN_HUMAN (10-190): 7.41e-58: 186: 61.54		ERBIN_HUMAN (1040-1271): 3.37e-10: 67.8: 24.54