HitPredict

Interactor 1: RAS2 (P01120)
Ras-like protein 2 (EC 3.6.5.2)
Gene: RAS2

Interactor 2: IRA2 (P19158)
Inhibitory regulator protein IRA2
Gene: IRA2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11412100, 8106517
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005739 - mitochondrion GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Sc			1 3079
+	Sc
		350792 RAS2_YEAST (1-322): 2.57e-88: 269: 100.00		IRA1_YEAST (15-3078): 0: 3868: 44.79
+	Hs
		349121 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		NF1_HUMAN (1243-2854): 0: 1709: 20.10
+	Hs
		349875 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		NF1_HUMAN (1243-2854): 0: 1709: 20.10
+	Hs
		914291 RB11A_HUMAN (4-218): 3.25e-86: 259: 27.32		SYGP1_HUMAN (1642-2047): 6.94e-102: 362: 16.75
+	Hs
		918932 RAB1A_HUMAN (2-203): 5.26e-81: 246: 29.06		SYGP1_HUMAN (1642-2047): 6.94e-102: 362: 16.75
+	Mm
		99942 RAB1A_MOUSE (2-203): 5.26e-81: 246: 29.06		SYGP1_MOUSE (1642-2047): 6.78e-101: 359: 16.75
+	Mm
		99927 RAB2A_MOUSE (1-216): 1.36e-77: 237: 29.49		SYGP1_MOUSE (1642-2047): 6.78e-101: 359: 16.75
+	Hs
		201878 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		RASL2_HUMAN (1639-2108): 1.45e-121: 407: 17.10
+	Hs
		914440 RB11A_HUMAN (4-218): 3.25e-86: 259: 27.32		NGAP_HUMAN (1574-1962): 2.13e-93: 333: 17.71
+	Hs
		895315 RAB2A_HUMAN (1-216): 2.11e-77: 237: 29.49		NGAP_HUMAN (1574-1962): 2.13e-93: 333: 17.71
+	Hs
		350460 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		SYGP1_HUMAN (1642-2047): 6.94e-102: 362: 16.75
+	Hs
		350243 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		DAB2P_HUMAN (1574-1973): 4.03e-102: 360: 16.99
+	Hs
		350662 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		NGAP_HUMAN (1574-1962): 2.13e-93: 333: 17.71
+	Hs
		349120 RASH_HUMAN (10-172): 4.41e-58: 187: 64.42		RASA1_HUMAN (1575-1989): 5.3e-91: 324: 19.77
+	Hs
		349874 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		RASA1_HUMAN (1575-1989): 5.3e-91: 324: 19.77
+	Hs
		809235 RAB2A_HUMAN (1-216): 2.11e-77: 237: 29.49		IQGA1_HUMAN (1665-1999): 1.29e-66: 253: 16.25
+	Hs
		809252 RAP1A_HUMAN (8-171): 1.27e-61: 196: 59.39		IQGA1_HUMAN (1665-1999): 1.29e-66: 253: 16.25
+	Hs
		349964 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		IQGA1_HUMAN (1665-1999): 1.29e-66: 253: 16.25
+	Sc
		533758 RSR1_YEAST (8-277): 1.17e-84: 258: 37.00		BUD2_YEAST (1708-1949): 2.31e-27: 124: 14.87
+	Hs
		350149 RASK_HUMAN (10-172): 1.82e-58: 187: 64.42		IQGA2_HUMAN (1718-1961): 2.02e-18: 95.6: 19.80