HitPredict

Interactor 1: PDGFB (P01127)
Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)
Gene: PDGFB

Interactor 2: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 20577048, 18593464, 11297552, 20534510, 17981115, 7679113, 10806482
Identification Methods affinity chromatography technology, pull down, unspecified method, cross-linking study, x-ray crystallography, molecular sieving, enzyme linked immunosorbent assay, competition binding
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PDGF~ig, Ig_3~PDGF
Common GO terms GO:0005161 - platelet-derived growth factor receptor binding
GO:0005737 - cytoplasm
GO:0008284 - positive regulation of cell population proliferation
GO:0014911 - positive regulation of smooth muscle cell migration
GO:0018108 - peptidyl-tyrosine phosphorylation
and 14 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 241
Hs

1 1106
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024