HitPredict

Interactor 1: PDGFB (P01127)
Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)
Gene: PDGFB

Interactor 2: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.735

The method score is based on:

Property Details
Experiments 9677323, 15767546, 2544881, 11297552, 7679113, 10806482
Identification Methods pull down, cross-linking study, competition binding, enzyme linked immunosorbent assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005161 - platelet-derived growth factor receptor binding
GO:0005737 - cytoplasm
GO:0008284 - positive regulation of cell population proliferation
GO:0010544 - negative regulation of platelet activation
GO:0018108 - peptidyl-tyrosine phosphorylation
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 241
Hs

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Last updated: 15 Jul 2024