HitPredict

Interactor 1: PDGFB (P01127)
Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)
Gene: PDGFB

Interactor 2: FREM2 (Q5SZK8)
FRAS1-related extracellular matrix protein 2 (ECM3 homolog)
Gene: FREM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007507 - heart development GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 3169
+	Hs
		350976 PDGFB_HUMAN (1-241): 1.13e-102: 299: 100.00		FAT4_HUMAN (208-1746): 0: 661: 11.21
+	Hs
		350986 PDGFB_HUMAN (1-241): 1.13e-102: 299: 100.00		FAT3_HUMAN (92-1676): 3.38e-176: 615: 11.47
+	Hs
		350967 PDGFB_HUMAN (1-241): 1.13e-102: 299: 100.00		FAT1_HUMAN (1072-2628): 6.04e-149: 526: 10.83
+	Hs
		834226 VEGFB_HUMAN (85-213): 5.08e-37: 130: 26.36		FAT1_HUMAN (1072-2628): 6.04e-149: 526: 10.83
+	Hs
		350988 PDGFB_HUMAN (1-241): 1.13e-102: 299: 100.00		AGRV1_HUMAN (525-2323): 9.4e-31: 136: 14.81
+	Hs
		217392 VEGFD_HUMAN (1-235): 1.5e-53: 177: 22.43		FRAS1_HUMAN (1065-2550): 1.86e-50: 201: 15.01