HitPredict - High confidence protein-protein interactions

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: APOE (P02649)
Apolipoprotein E (Apo-E)
Gene: APOE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	20030366, 24447298
Identification Methods	pull down, nuclear magnetic resonance, surface plasmon resonance
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0006898 - receptor-mediated endocytosis and 16 others more... GO:0007616 - long-term memory GO:0008203 - cholesterol metabolic process GO:0010629 - negative regulation of gene expression GO:0016020 - membrane GO:0030669 - clathrin-coated endocytic vesicle membrane GO:0034362 - low-density lipoprotein particle GO:0034384 - high-density lipoprotein particle clearance GO:0042159 - lipoprotein catabolic process GO:0042632 - cholesterol homeostasis GO:0048844 - artery morphogenesis GO:0051246 - regulation of protein metabolic process GO:0051248 - negative regulation of protein metabolic process GO:0061771 - response to caloric restriction GO:0071813 - lipoprotein particle binding GO:0090181 - regulation of cholesterol metabolic process GO:1905907 - negative regulation of amyloid fibril formation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	860
Hs

1	317

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024