HitPredict

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: AMRP (P30533)
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)
Gene: LRPAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	7822276, 28514442, 33961781, 20030366
Identification Methods	pull down, affinity chromatography technology, nuclear magnetic resonance, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Alpha-2-MRAP_C~Ldl_recept_a, Alpha-2-MRAP_N~Ldl_recept_a
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 860 Hs			1 357
+	Hs
		674662 LRP8_HUMAN (26-851): 0: 565: 45.42		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Gg
		223337 VLDLR_CHICK (6-859): 0: 584: 47.73		O57378_CHICK (27-357): 1.68e-131: 381: 67.87
+	Hs
		254247 LRP4_HUMAN (664-846): 1.85e-17: 89.9: 14.75		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674650 VLDLR_HUMAN (187-454): 1.14e-15: 83.7: 21.56		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674651 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674705 SORL_HUMAN (17-104): 1.75e-09: 63.9: 43.33		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674731 LRP1B_HUMAN (21-229): 6.4e-09: 62.2: 16.82		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Hs
		674653 LRP1_HUMAN (155-417): 9.84e-09: 61.8: 8.73		AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00
+	Gg
		223338 LRP8_CHICK (190-423): 7.57e-13: 74.5: 21.37		O57378_CHICK (27-357): 1.68e-131: 381: 67.87
+	Dm
		65980 A8JRC4_DROME (234-428): 1.49e-09: 64.1: 21.72		Q9VH64_DROME (15-357): 2.22e-98: 298: 31.84