HitPredict

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: FCGRN (P55899)
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Gene: FCGRT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009897 - external side of plasma membrane GO:0010008 - endosome membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 860 Hs			1 365
+	Hs
		270262 LRP6_HUMAN (194-374): 7.63e-12: 71.8: 26.60		HLAG_HUMAN (1-307): 6.38e-133: 384: 27.36
+	Hs
		258295 LRP5_HUMAN (195-364): 1.29e-10: 67.5: 26.14		HLAG_HUMAN (1-307): 6.38e-133: 384: 27.36
+	Hs
		254251 LRP4_HUMAN (664-846): 1.85e-17: 89.9: 14.75		FCGRN_HUMAN (1-365): 7.52e-116: 342: 100.00
+	Hs
		270278 LRP6_HUMAN (194-374): 7.63e-12: 71.8: 26.60		FCGRN_HUMAN (1-365): 7.52e-116: 342: 100.00
+	Hs
		258300 LRP5_HUMAN (195-364): 1.29e-10: 67.5: 26.14		FCGRN_HUMAN (1-365): 7.52e-116: 342: 100.00