HitPredict

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11247302
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006898 - receptor-mediated endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 860 Hs			1 770
+	Hs
		351073 LDLR_HUMAN (1-860): 0: 697: 100.00		ARH_HUMAN (13-293): 3.15e-56: 197: 13.54
+	Hs
		957177 LRP8_HUMAN (26-851): 0: 565: 45.42		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		269114 LDLR_HUMAN (1-860): 0: 697: 100.00		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Mm
		956234 LRP8_MOUSE (3-851): 0: 604: 49.66		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		269145 LRP8_HUMAN (26-851): 0: 565: 45.42		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Hs
		253558 LRP8_HUMAN (26-851): 0: 565: 45.42		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Hs
		270287 LRP6_HUMAN (194-374): 7.63e-12: 71.8: 26.60		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		957165 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Rn
		292326 LRP2_RAT (185-425): 4.11e-12: 72.6: 21.79		DAB2_RAT (1-770): 2.88e-78: 269: 80.34
+	Hs
		957612 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		ARH_HUMAN (13-293): 3.15e-56: 197: 13.54
+	Rn
		88518 LRP2_RAT (185-425): 4.11e-12: 72.6: 21.79		ARH_RAT (13-293): 4.42e-51: 182: 13.94
+	Mm
		729617 LDLR_MOUSE (5-197): 3.55e-17: 88.7: 20.62		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		269133 VLDLR_HUMAN (187-454): 1.14e-15: 83.7: 21.56		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Ce
		60773 LRP_CAEEL (5-246): 5.75e-19: 95.3: 24.31		A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06
+	Hs
		957621 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		ANS1B_HUMAN (12-227): 1.36e-43: 172: 19.01
+	Mm
		956222 VLDLR_MOUSE (187-454): 6.02e-15: 81.4: 21.56		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		269134 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Mm
		69879 B1AXJ3_MOUSE (3-145): 3.28e-10: 66: 19.88		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Ce
		60768 O01768_CAEEL (102-302): 5.86e-10: 65.6: 23.15		A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06
+	Hs
		253552 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91