HitPredict

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: TAFA3 (Q7Z5A8)
Chemokine-like protein TAFA-3
Gene: TAFA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:1903979 - negative regulation of microglial cell activation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 860 Hs			1 133
+	Hs
		351086 LDLR_HUMAN (1-860): 0: 697: 100.00		TAFA2_HUMAN (1-132): 6.63e-66: 197: 62.88
+	Hs
		957620 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		TAFA3_HUMAN (1-133): 1.43e-67: 201: 100.00
+	Hs
		270312 LRP6_HUMAN (194-374): 7.63e-12: 71.8: 26.60		TAFA2_HUMAN (1-132): 6.63e-66: 197: 62.88
+	Hs
		1190913 SORL_HUMAN (17-104): 1.75e-09: 63.9: 43.33		TAFA3_HUMAN (1-133): 1.43e-67: 201: 100.00
+	Hs
		1190932 LRP1B_HUMAN (21-229): 6.4e-09: 62.2: 16.82		TAFA3_HUMAN (1-133): 1.43e-67: 201: 100.00
+	Hs
		1232364 SORL_HUMAN (17-104): 1.75e-09: 63.9: 43.33		TAFA2_HUMAN (1-132): 6.63e-66: 197: 62.88
+	Hs
		957632 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		TAFA4_HUMAN (14-133): 5.5e-52: 162: 66.67
+	Hs
		1269012 SORL_HUMAN (17-104): 1.75e-09: 63.9: 43.33		TAFA4_HUMAN (14-133): 5.5e-52: 162: 66.67