HitPredict

Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Interactor 2: NET5 (Q8WTR8)
Netrin-5 (Netrin-1-like protein)
Gene: NTN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Laminin_EGF~Ldl_recept_b
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 860 Hs			1 489
+	Hs
		624332 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		TENA_HUMAN (10-342): 2.3e-43: 166: 12.43
+	Hs
		502831 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMC1_HUMAN (124-444): 6.82e-27: 117: 18.77
+	Hs
		877411 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMB2_HUMAN (89-313): 5.5e-20: 96: 17.80
+	Hs
		1048403 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMA4_HUMAN (252-383): 1.09e-17: 88.7: 17.29
+	Dm
		53032 NDG_DROME (26-698): 5.79e-111: 371: 23.47		LAMB1_DROME (19-313): 5.72e-17: 86.4: 17.59
+	Hs
		433149 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMB1_HUMAN (27-313): 2.64e-13: 74.8: 16.38
+	Hs
		172664 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMA5_HUMAN (2-279): 1.23e-10: 66.4: 14.13
+	Hs
		631066 NID2_HUMAN (29-658): 3.64e-112: 375: 19.34		LAMA1_HUMAN (7-221): 2.35e-10: 65.6: 11.84
+	Dm
		53035 NDG_DROME (26-698): 5.79e-111: 371: 23.47		LAMA_DROME (4-222): 2.52e-11: 68.7: 11.71
+	Hs
		254285 LRP4_HUMAN (664-846): 1.85e-17: 89.9: 14.75		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		957630 LRP2_HUMAN (677-844): 3.13e-11: 69.9: 15.48		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259455 SORL_HUMAN (17-104): 1.75e-09: 63.9: 43.33		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259459 LRP1B_HUMAN (21-229): 6.4e-09: 62.2: 16.82		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Dm
		1098542 Q8IRV8_DROME (22-123): 8.33e-13: 75.1: 33.04		NETB_DROME (143-472): 9.84e-53: 192: 31.10
+	Dm
		52252 A1Z7C4_DROME (66-248): 1.15e-09: 64.8: 21.89		LAMC1_DROME (20-327): 1.21e-27: 119: 15.82
+	Hs
		502808 NID1_HUMAN (712-843): 7.17e-10: 65.2: 12.78		LAMC1_HUMAN (124-444): 6.82e-27: 117: 18.77
+	Hs
		537530 NID1_HUMAN (712-843): 7.17e-10: 65.2: 12.78		LAMC3_HUMAN (20-326): 3.25e-27: 117: 17.98
+	Mm
		358675 NID1_MOUSE (1-246): 1.69e-15: 83.3: 13.03		LAMC1_MOUSE (240-449): 3.8e-14: 77.5: 13.33
+	Dm
		52251 A1Z7C4_DROME (66-248): 1.15e-09: 64.8: 21.89		LAMB1_DROME (19-313): 5.72e-17: 86.4: 17.59
+	Dm
		52257 A1Z7C4_DROME (66-248): 1.15e-09: 64.8: 21.89		LAMA_DROME (4-222): 2.52e-11: 68.7: 11.71