HitPredict

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 15597342, 8235612, 10716993, 10187774, 7706250, 20856203
Identification Methods pull down, affinity chromatography technology, biochemical, coimmunoprecipitation, cross-linking study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~TGF_beta
Common GO terms GO:0001837 - epithelial to mesenchymal transition
GO:0005114 - type II transforming growth factor beta receptor binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0007179 - transforming growth factor beta receptor signaling pathway
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 390
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024