HitPredict

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: ACVL1 (P37023)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 0.60 0.676

The method score is based on:

Property Details
Experiments 10716993, 8242742, 10187774, 18333754
Identification Methods affinity chromatography technology, coimmunoprecipitation, cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0007507 - heart development
GO:0008285 - negative regulation of cell population proliferation
GO:0009986 - cell surface
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 390
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024