HitPredict

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 8389764, 11157754, 8242742, 9261125, 7878020, 7706250, 10026191, 18382895, 15034927, 35443807, 20860622, 20856203, 21441952, 21054789
Identification Methods pull down, affinity chromatography technology, coimmunoprecipitation, surface plasmon resonance, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, cross-linking study, solid phase assay
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains TGF_beta~ecTbetaR2
Common GO terms GO:0001570 - vasculogenesis
GO:0001837 - epithelial to mesenchymal transition
GO:0003180 - aortic valve morphogenesis
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 13 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 390
Hs

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Last updated: 15 Jul 2024