HitPredict - High confidence protein-protein interactions

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: TGFB2 (P61812)
Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
Gene: TGFB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27684187, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TGF_beta~TGF_beta, TGF_beta~TGFb_propeptide, TGFb_propeptide~TGFb_propeptide
Common GO terms	GO:0000902 - cell morphogenesis GO:0001837 - epithelial to mesenchymal transition GO:0001843 - neural tube closure GO:0003179 - heart valve morphogenesis GO:0005114 - type II transforming growth factor beta receptor binding and 30 others more... GO:0005125 - cytokine activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0007435 - salivary gland morphogenesis GO:0007507 - heart development GO:0008083 - growth factor activity GO:0008284 - positive regulation of cell population proliferation GO:0008285 - negative regulation of cell population proliferation GO:0009611 - response to wounding GO:0010629 - negative regulation of gene expression GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0010936 - negative regulation of macrophage cytokine production GO:0030308 - negative regulation of cell growth GO:0030424 - axon GO:0031093 - platelet alpha granule lumen GO:0032570 - response to progesterone GO:0034714 - type III transforming growth factor beta receptor binding GO:0042127 - regulation of cell population proliferation GO:0043025 - neuronal cell body GO:0045216 - cell-cell junction organization GO:0048839 - inner ear development GO:0050680 - negative regulation of epithelial cell proliferation GO:0050714 - positive regulation of protein secretion GO:0051781 - positive regulation of cell division GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0060391 - positive regulation of SMAD protein signal transduction GO:0062023 - collagen-containing extracellular matrix GO:0097191 - extrinsic apoptotic signaling pathway GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	390
Hs

1	414

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Last updated: 15 Jul 2024