HitPredict

Interactor 1: NGF (P01138)
Beta-nerve growth factor (Beta-NGF)
Gene: NGF

Interactor 2: SORT (Q99523)
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Gene: SORT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	14985763, 20159974, 19122660
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NGF~Sortilin-Vps10
Common GO terms	GO:0005829 - cytosol GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 241 Hs			1 831
+	Mm
		351498 NGF_MOUSE (1-241): 2.79e-143: 402: 85.06		SORT_MOUSE (1-831): 0: 1048: 90.61
+	Hs
		595723 NTF3_HUMAN (1-239): 2.5e-130: 369: 42.02		SORT_HUMAN (1-831): 0: 1064: 100.00
+	Hs
		618296 BDNF_HUMAN (1-239): 4e-109: 315: 35.74		SORT_HUMAN (1-831): 0: 1064: 100.00
+	Hs
		351493 NGF_HUMAN (1-241): 2.09e-137: 387: 100.00		SORC2_HUMAN (25-742): 0: 768: 24.17
+	Hs
		351495 NGF_HUMAN (1-241): 2.09e-137: 387: 100.00		SORC3_HUMAN (25-755): 0: 757: 23.48
+	Hs
		595722 NTF3_HUMAN (1-239): 2.5e-130: 369: 42.02		SORC2_HUMAN (25-742): 0: 768: 24.17
+	Hs
		618295 BDNF_HUMAN (1-239): 4e-109: 315: 35.74		SORC2_HUMAN (25-742): 0: 768: 24.17