HitPredict

Interactor 1: COLI (P01189)
Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin]
Gene: POMC

Interactor 2: MC4R (P32245)
Melanocortin receptor 4 (MC4-R)
Gene: MC4R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11101306, 9058374
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~ACTH_domain
Common GO terms	GO:0005737 - cytoplasm GO:1990680 - response to melanocyte-stimulating hormone
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 267 Hs			1 332
+	Hs
		351597 COLI_HUMAN (1-267): 0: 502: 100.00		MSHR_HUMAN (25-319): 5.93e-79: 245: 50.34
+	Hs
		351593 COLI_HUMAN (1-267): 0: 502: 100.00		MC3R_HUMAN (25-320): 2.59e-61: 200: 60.73
+	Hs
		351592 COLI_HUMAN (1-267): 0: 502: 100.00		MC5R_HUMAN (9-331): 6.45e-61: 199: 61.42