HitPredict - High confidence protein-protein interactions

Interactor 1: SOMA (P01241)
Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone)
Gene: GH1

Interactor 2: GHR (P10912)
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Gene: GHR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.961

Property	Details
Experiments	7862673, 17500058, 24280222, 9571026, 8943276, 9353194, 31279174
Identification Methods	pull down, biochemical, surface plasmon resonance, x-ray crystallography, classical fluorescence spectroscopy
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	EpoR_lig-bind~Hormone_1, Hormone_1~fn3
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0019221 - cytokine-mediated signaling pathway GO:0032355 - response to estradiol and 6 others more... GO:0040018 - positive regulation of multicellular organism growth GO:0042531 - positive regulation of tyrosine phosphorylation of STAT protein GO:0043406 - positive regulation of MAP kinase activity GO:0046427 - positive regulation of receptor signaling pathway via JAK-STAT GO:0060396 - growth hormone receptor signaling pathway GO:0070195 - growth hormone receptor complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	217
Hs

1	638

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024