Interactor 1: GLUC (P01275)
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]
Gene: GCG
Interactor 2: GIPR (P48546)
Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor)
Gene: GIPR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.692 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17715056 |
| Identification Methods | isothermal titration calorimetry, circular dichroism |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 7tm_2~Hormone_2, HRM~Hormone_2 |
| Common GO terms | GO:0005886 - plasma membrane GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0050796 - regulation of insulin secretion |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
