HitPredict

Interactor 1: IGF2 (P01344)
Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
Gene: IGF2

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

The method score is based on:

Property	Details
Experiments	33961781, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Insulin~fn3, Furin-like~Insulin, Insulin~Recep_L_domain
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding GO:0006355 - regulation of DNA-templated transcription GO:0008284 - positive regulation of cell population proliferation GO:0008286 - insulin receptor signaling pathway GO:0031017 - exocrine pancreas development and 4 others more... GO:0043410 - positive regulation of MAPK cascade GO:0045725 - positive regulation of glycogen biosynthetic process GO:0045840 - positive regulation of mitotic nuclear division GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	180
Hs

1	1382

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024