HitPredict

Interactor 1: IGF2 (P01344)
Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
Gene: IGF2

Interactor 2: IBP5 (P24593)
Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)
Gene: IGFBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.799

The method score is based on:

Property Details
Experiments 33961781, 9497324
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Insulin, Insulin~Thyroglobulin_1
Common GO terms GO:0001649 - osteoblast differentiation
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0048009 - insulin-like growth factor receptor signaling pathway
GO:0051146 - striated muscle cell differentiation
and 1 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 180
Hs

1 272
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024