Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 15173183, 1331108, 32968279, 19838188, 2922050, 9488135, 23815148
Identification Methods pull down, affinity chromatography technology, cross-linking study, molecular sieving, x-ray crystallography, blue native page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNF
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001666 - response to hypoxia
GO:0001774 - microglial cell activation
GO:0001819 - positive regulation of cytokine production
and 185 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 233
Hs

1 233
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Last updated: 15 Jul 2024