HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 644
+	Hs
		352440 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44
+	Hs
		352452 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33
+	Hs
		213923 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		KRT86_HUMAN (79-558): 5.38e-84: 274: 43.69
+	Hs
		352467 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32