HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24012417
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 325
+	Mm
		420386 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IRF1_MOUSE (1-325): 2.47e-161: 455: 84.50
+	Hs
		501016 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF1_HUMAN (1-325): 2.66e-166: 467: 100.00
+	Mm
		420389 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IRF8_MOUSE (7-270): 2.81e-94: 287: 28.03
+	Hs
		352614 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Hs
		536494 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55
+	Hs
		841072 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Hs
		841070 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF5_HUMAN (2-297): 2.67e-54: 186: 24.05