HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 101
+	Hs
		352505 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AB_HUMAN (2-97): 2.99e-36: 120: 27.84
+	Hs
		352545 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AA_HUMAN (1-100): 4.52e-32: 109: 34.00
+	Hs
		352442 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10A6_HUMAN (1-92): 1.7e-28: 100: 50.00
+	Hs
		352578 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AC_HUMAN (3-87): 4.08e-28: 99.1: 35.29
+	Hs
		352693 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AD_HUMAN (3-84): 4.72e-22: 84.1: 34.15