HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27307491, 30420664, 35941131
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 716
+	Hs
		352717 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Mm
		420410 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		TBK1_MOUSE (1-714): 2.98e-162: 486: 46.78
+	Mm
		420408 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IKKE_MOUSE (1-716): 1.49e-161: 485: 82.34
+	Hs
		158362 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167437 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Mm
		291434 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10