HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27307491
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 712
+	Hs
		352712 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Rn
		561424 TNFA_RAT (1-233): 1.51e-91: 270: 78.39		TAB2_RAT (1-711): 3.62e-45: 174: 28.09
+	Hs
		352729 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		ZAN_HUMAN (78-482): 1.43e-12: 73.6: 11.77