HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: CR3L1 (Q96BA8)
Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1]
Gene: CREB3L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0010629 - negative regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 519
+	Hs
		352587 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		CREM_HUMAN (67-341): 6.74e-34: 133: 18.55
+	Mm
		420385 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		JUNB_MOUSE (69-367): 3.93e-34: 133: 15.11
+	Hs
		216643 TNFB_HUMAN (58-233): 1.45e-43: 147: 30.06		CREB3_HUMAN (154-505): 3.52e-48: 172: 27.05
+	Hs
		216746 Q6FG55_HUMAN (58-233): 2.06e-43: 146: 30.06		CREB3_HUMAN (154-505): 3.52e-48: 172: 27.05