HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27307491, 22675546
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043122 - regulation of canonical NF-kappaB signal transduction
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 577
+	Hs
		352734 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Mm
		291774 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33
+	Hs
		352510 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08