HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: S10AD (Q99584)
Protein S100-A13 (S100 calcium-binding protein A13)
Gene: S100A13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	36555597
Identification Methods	pull down, surface plasmon resonance, cross-linking study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001819 - positive regulation of cytokine production GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 98
+	Hs
		352505 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AB_HUMAN (6-91): 2.44e-30: 105: 35.96
+	Hs
		352545 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AA_HUMAN (6-98): 1.32e-29: 102: 26.04
+	Hs
		352500 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10A4_HUMAN (8-91): 1.71e-26: 95.3: 32.18
+	Hs
		352578 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AC_HUMAN (6-88): 3.59e-25: 91.8: 33.72
+	Hs
		352442 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10A6_HUMAN (8-91): 2.55e-23: 86.8: 31.77