HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	27307491, 27545878, 32968279, 20005846, 16603398
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 693
+	Rn
		561424 TNFA_RAT (1-233): 1.51e-91: 270: 78.39		TAB2_RAT (1-693): 1.35e-107: 343: 93.94
+	Hs
		352658 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		352729 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		ZAN_HUMAN (196-525): 5.32e-15: 81.7: 12.20