HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	30561431, 26670046, 27560715, 27307491, 30420664, 33815386, 34315543, 34610306, 20005846, 16603398, 23032187, 23032186, 23104095
Identification Methods	affinity chromatography technology, virotrap, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0009615 - response to virus GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 419
+	Hs
		352682 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Mm
		291774 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		352730 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		352510 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93