HitPredict

Interactor 1: IFNA2 (P01563)
Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
Gene: IFNA2

Interactor 2: INAR2 (P48551)
Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
Gene: IFNAR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.953

Property	Details
Experiments	10339405, 10395669, 10984492, 17001036, 18027911, 21854986
Identification Methods	pull down, biochemical, surface plasmon resonance, nuclear magnetic resonance, solid phase assay, cross-linking study, x-ray crystallography
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	Interfer-bind~Interferon, Interferon~Tissue_fac
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007166 - cell surface receptor signaling pathway GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway and 1 others more... GO:0098586 - cellular response to virus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 188 Hs			1 515
+	Hs
		352827 IFNA5_HUMAN (1-188): 5.06e-103: 296: 83.60		INAR2_HUMAN (1-515): 0: 906: 100.00
+	Hs
		352750 IFNA1_HUMAN (1-188): 3.15e-100: 288: 82.01		INAR2_HUMAN (1-515): 0: 906: 100.00
+	Hs
		699608 IFNA8_HUMAN (1-188): 7.94e-95: 275: 82.01		INAR2_HUMAN (1-515): 0: 906: 100.00
+	Hs
		392909 IFNW1_HUMAN (12-188): 1.67e-78: 234: 60.11		INAR2_HUMAN (1-515): 0: 906: 100.00
+	Hs
		352874 IFNB_HUMAN (1-186): 8.31e-49: 158: 32.98		INAR2_HUMAN (1-515): 0: 906: 100.00