HitPredict

Interactor 1: IFNA2 (P01563)
Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
Gene: IFNA2

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	19349300, 11473119
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 188 Hs			1 427
+	Hs
		352755 IFNA1_HUMAN (1-188): 3.15e-100: 288: 82.01		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352844 IFN14_HUMAN (1-188): 2.95e-99: 286: 82.01		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352788 IFNA7_HUMAN (1-188): 1.28e-98: 285: 77.78		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Mm
		427402 IFNA4_MOUSE (1-188): 3.54e-81: 240: 55.26		IRF3_MOUSE (1-425): 0: 534: 71.06
+	Hs
		352753 IFNA1_HUMAN (1-188): 3.15e-100: 288: 82.01		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		352842 IFN14_HUMAN (1-188): 2.95e-99: 286: 82.01		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Mm
		427399 IFNA4_MOUSE (1-188): 3.54e-81: 240: 55.26		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Mm
		427400 IFNA4_MOUSE (1-188): 3.54e-81: 240: 55.26		IRF5_MOUSE (2-413): 1.06e-144: 423: 29.81
+	Mm
		427401 IFNA4_MOUSE (1-188): 3.54e-81: 240: 55.26		IRF7_MOUSE (2-383): 2.84e-131: 387: 27.92
+	Hs
		352775 IFNA2_HUMAN (1-188): 1.27e-103: 297: 100.00		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352758 IFNA1_HUMAN (1-188): 3.15e-100: 288: 82.01		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352848 IFN14_HUMAN (1-188): 2.95e-99: 286: 82.01		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352791 IFNA7_HUMAN (1-188): 1.28e-98: 285: 77.78		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352878 IFNB_HUMAN (1-186): 8.31e-49: 158: 32.98		IRF8_HUMAN (7-387): 6.94e-148: 428: 27.32
+	Hs
		352882 IFNB_HUMAN (1-186): 8.31e-49: 158: 32.98		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		352766 IFNA2_HUMAN (1-188): 1.27e-103: 297: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352745 IFNA1_HUMAN (1-188): 3.15e-100: 288: 82.01		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352837 IFN14_HUMAN (1-188): 2.95e-99: 286: 82.01		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352861 IFNB_HUMAN (1-186): 8.31e-49: 158: 32.98		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352862 IFNB_HUMAN (1-186): 8.31e-49: 158: 32.98		IRF2_HUMAN (1-116): 1.85e-48: 170: 33.90